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Recombinant Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16 Antibody [CDH16/1532R]

In Stock
Catalog Number Formulation Size Price
1014-RBM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
1014-RBM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
1014-RBM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16 Antibody

Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with KSP-Cadherin Rabbit Recombinant Monoclonal Antibody (CDH16/1532R)

Recombinant Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16 Antibody - Image 2

Formalin-fixed, paraffin-embedded Rat Kidney stained with KSP-Cadherin Rabbit Recombinant Monoclonal Antibody (CDH16/1532R)

Recombinant Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16 Antibody - Image 3

Formalin-fixed, paraffin-embedded Mouse Kidney stained with KSP-Cadherin Rabbit Recombinant Monoclonal Antibody (CDH16/1532R)

Recombinant Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16 Antibody - Image 4

SDS-PAGE Analysis of Purified KSP-Cadherin Rabbit Recombinant Monoclonal Antibody (CDH16/1532R)

Recombinant Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16 Antibody - Image 5

Western Blot Analysis of human Kidney lysate using KSP-Cadherin Rabbit Recombinant Monoclonal Antibody (CDH16/1532R)

Recombinant Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16 Antibody - Image 6

Flow Cytometric Analysis of Human HEK293 cells using KSP-Cadherin Recombinant Rabbit Monoclonal Antibody (CDH16/1532R) followed by Goat anti-rabbit IgG-CF488 (Blue); Isotype Control (Red).

Applications & Dilutions

Applications Tested Dillution Protocol Note
Flow Cytometry (Flow)
1-2ug/million cells
Flow Cytometry Protocol
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)
2-4ug/ml
Western Blot Protocol

Summary

This MAb recognizes a protein of 130kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels.Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.

Product Properties & Targets

Antibody Type
Rabbit Monoclonals, Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Flow Cytometry, Immunohistochemistry, Western Blot
Species Reactivity
Human, Mouse, Rat
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Cell membrane
Gene Name
CDH16
Positive Control
Normal kidney or renal cell carcinoma.
Immunogen
Recombinant human full-length CDH16 protein
Alternate Names
Cadherin-16, Kidney-specific cadherin, Cadherin-16 (CDH16); Kidney-specific cadherin; Ksp-cadherin antibody

Database Links

Entrez Gene ID
1014
SwissProt
O75309

Additional Information

Clone
CDH16/1532R
Chromosome Location
16q22.1
Mol. Weight of Antigen
130kDa

Related Antibodies

View All CDH16 Antibodies

Functions

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Key References

  • Shen, S.S., et al. 2005. Kidney-specific cadherin, a specific marker for the distal portion of the nephron and related renal neoplasms. Mod Pathol. 18: 933-40.
  • Mazal, P.R., et al. 2005. Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma. Hum Pathol. 36: 22-28.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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