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Recombinant L-PLUNC Antibody [LPLUNC1/7059R]

In Stock
Catalog Number Formulation Size Price
92747-RBM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
92747-RBM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
92747-RBM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)
2-4ug/ml

Summary

The upper respiratory tract is the main place of entry for pathogens to invade the body, and early recognition of bacterial products in this region is crucial for host defense. Palate lung nasal epithelial clone PLUNC (or LUNX) is an airway specific secretory protein that is expressed in epithelial tissues and submucosal glands of the oral cavity and upper respiratory tract of humans, mice, rats and cows. PLUNC binds to lipopolysaccharide (LPS) in nasal lavage fluid (NLF) which points to its role in the inflammatory response of the upper airways after exposure to irritants. Decreased levels of PLUNC occur in the NLF of smokers and people who have been exposed to reactive epoxy chemicals, indicating that long-term exposure to airway irritants impairs the production of PLUNC in the upper respiratory tract. Abnormal expression of PLUNC may influence susceptibility to nasopharyngeal carcinoma in the Chinese population.

Product Properties & Targets

Host
Rabbit
Species Reactivity
Research Areas
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Secreted
Gene Name
Positive Control
Human lung or tonsil. HeLa cells.
Immunogen
Recombinant full-length human BPIFB1 protein
Alternate Names
BPI fold-containing family B member 1, Long palate, lung and nasal epithelium carcinoma-associated protein 1, von Ebner minor salivary gland protein, BPI fold containing family B, member 1; Long palate, lung and nasal epithelium carcinoma associated protein 1 (Lplunc1); lung and nasal epithelium carcinoma-associated protein 1; VEMSGP; Von Ebner minor salivary gland protein

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
LPLUNC1/7059R
Chromosome Location
20q11.21
Mol. Weight of Antigen
25kDa

Functions

  • May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS.

Key References

  • J Immunol. 2011 Jul 1;187(1):382-90.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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