Free Shipping in the U.S. for orders over $1000.  Shop Now>>

Printable Datasheet

MRP1 / ABCC1 (Multidrug Resistance Related Protein 1) Antibody [MRP1/1344]

In Stock
Catalog Number Formulation Size Price
4363-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
4363-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
4363-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
MRP1 / ABCC1 (Multidrug Resistance Related Protein 1) Antibody

SDS-PAGE Analysis of Purified MRP1 Mouse Monoclonal Antibody (MRP1/1344). Confirmation of Integrity and Purity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Flow Cytometry Protocol
Immunofluorescence (IF)
1-3ug/ml

Summary

The two members of the large family of ABC transporters known to confer multidrug resistance in human cancer cells are the MDR1 P-glycoprotein and the multidrug-resistance protein MRP1. MRP1 is an integral membrane protein that contains an MDR-like core, an N-terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Immunofluorescence
Species Reactivity
Human
Research Areas
Cardiovascular
Isotype / Light Chain
IgG2a / Kappa
Cellular Localization
Cell membrane
Gene Name
ABCC1
Positive Control
A549 cells. Colon, Endometrium, Ovary. Testis or Tonsil.
Immunogen
Recombinant full-length human ABCC1 protein
Alternate Names
Multidrug resistance-associated protein 1, ATP-binding cassette sub-family C member 1, Glutathione-S-conjugate-translocating ATPase ABCC1, Leukotriene C(4) transporter, ABC29; ABCC1; ATP binding cassette sub family C (CFTR/MRP) member 1; ATP-binding cassette sub-family C member 1; GSX; Leukotriene C(4) transporter; LTC4 transporter; Multidrug resistance-associated protein 1 (MRP1)

Database Links

Entrez Gene ID
4363
SwissProt
P33527

Additional Information

Clone
MRP1/1344
Chromosome Location
16p13.11
Mol. Weight of Antigen
190kDa

Related Antibodies

View All ABCC1 Antibodies

Functions

  • Mediates export of organic anions and drugs from the cytoplasm (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity).

Key References

  • Faneyte IF, Kristel PM, van de Vijver MJ. Multidrug resistance associated genes MRP1, MRP2 and MRP3 in primary and anthracycline exposed breast cancer. Anticancer Res. 2004;24(5A):2931-9.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

Reviews

There are no reviews yet.

Be the first to review “MRP1 / ABCC1 (Multidrug Resistance Related Protein 1) Antibody”

Your email address will not be published. Required fields are marked *

PARTNERSHIP OPPORTUNITIES

NeoBiotechnologies holds Exclusive rights to 10,000 recombinant and hybridoma antibody products, available for Licensing or Collaboration.

LETS TALK
Call Us Now: 1-866-2-NEOBIO (1-866-263-6246)
NeoBiotechnologies Logo
Company Info
Antibodies
Antibody Validation
Research Areas
Resources
Newsletter Signup Updates & Sales