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Myeloperoxidase / MPO Antibody [MPO/7116]

In Stock
Catalog Number Formulation Size Price
4353-MSM6-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
4353-MSM6-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
4353-MSM6-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
Formalin-fixed, paraffin-embedded human spleen stained with Myeloperoxidase Mouse Monoclonal Antibody (MPO/7116). Inset: PBS instead of primary antibody; secondary only negative control.

Formalin-fixed, paraffin-embedded human spleen stained with Myeloperoxidase Mouse Monoclonal Antibody (MPO/7116). Inset: PBS instead of primary antibody; secondary only negative control.

Formalin-fixed, paraffin-embedded human bone marrow stained with Myeloperoxidase Mouse Monoclonal Antibody (MPO/7116). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

Formalin-fixed, paraffin-embedded human bone marrow stained with Myeloperoxidase Mouse Monoclonal Antibody (MPO/7116). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Myeloperoxidase (MPO) also called the peroxidase (POD), is an important marker of bone marrow cells. It is one of the members of the family of heme peroxidase super existing in myeloid cells (mainly neutrophils and monocytes of aniline blue particles). With the deepening of the research on MPO, MPO gene polymorphism has been found to lead to individual for some disease susceptibility differences, with a variety of human development is closely related to the occurrence of diseases. The antibody reacts with neutrophil granulocytes and monocytes in blood and with precursors of granulocytes in the bone marrow. The antibody is useful as an aid for classification of neoplastic tissue, i.e. myeloblasts and immature myeloid cells of acute myelogenous leukemia, progranulocytic leukemia, monomyelocytic leukemia, erythroleukemia and myeloblastoma.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Cardiovascular, Immunology, Hematopoietic Stem Cells
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Lysosome
Gene Name
MPO
Positive Control
Human B cell lymphoma or liver tissue.
Immunogen
Recombinant fragment (around aa150-250) of human MPO protein (exact sequence is proprietary)
Alternate Names
Myeloperoxidase, 84 kDa / 89 kDa myeloperoxidase; EC 1.11.1.7; EC1.11.2.2; fj80f04; MPO; mpx; myeloid-specific peroxidase; Myeloperoxidase; Myeloperoxidase heavy chain; Myeloperoxidase light chain

Database Links

Entrez Gene ID
4353
SwissProt
P05164

Additional Information

Clone
MPO/7116
Chromosome Location
17q22
Mol. Weight of Antigen
heavy-light promoter: 72kDa; dimer: 140kDa

Related Antibodies

View All MPO Antibodies

Functions

  • Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity (PubMed:9922160). Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage (PubMed:25698971).

Key References

  • Toth B, Wehrmann M,et al. J Clin Pathol 1999 Sep;52(9):688-92.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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