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NK1.1 / CD161c / Klrb1c, Mouse Antibody [PK136]

In Stock
Catalog Number Formulation Size Price
MSM1-2010-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
MSM1-2010-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
MSM1-2010-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
NK1.1 / CD161c / Klrb1c, Mouse Antibody

SDS-PAGE Analysis of Purified NK1.1 Mouse Monoclonal Antibody (PK136). Confirmation of Integrity and Purity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Flow Cytometry Protocol
Immunofluorescence (IF)
1-3ug/ml

Summary

NK1.1 is a type II integral membrane glycoprotein with a C-type lectin domain and is encoded by theKlrb1c/NKR-P1Cgene.It is predominantly expressed as a disulfide-linked homodimer on NK cells however; it is also expressed on NK-T cells, a rare population of T lymphocytes.NK1.1 is expressed in some Mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cellsin vitroand rejection of bone marrow allograftsin vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN- production, and cytotoxic granule release. NK-1.1 is commonly used as a Mouse NK cell marker.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Functional Studies, Immunofluorescence
Species Reactivity
Mouse
Isotype / Light Chain
IgG2a / Kappa
Cellular Localization
Membrane
Gene Name
Klrb1c
Positive Control
MPBMC's or Thymus or Lymph Node.
Immunogen
CD Mouse spleen and bone marrow cells enriched for NK-1+ cells
Alternate Names
Killer cell lectin-like receptor subfamily B member 1C, CD161 antigen-like family member C, Lymphocyte antigen 55c, NK1.1, NKR-P1.9, NKR-P1C, Natural killer cell surface protein P1-40, CD161 antigen-like family member C; CD161c; Killer cell lectin-like receptor subfamily B member 1C (Klrb1c); Klrb1f; Lymphocyte antigen 55c (Ly55c); Lymphocyte antigen 59; Natural killer cell surface protein P1-40; NK1.1; NKR-P1 40; NKR-P1.9; NKR-P1C; NKRP1

Database Links

Entrez Gene ID
17059
SwissProt
P27814

Additional Information

Clone
PK136
Chromosome Location
6 F3; 6 63.09 cM (Mouse)
Mol. Weight of Antigen
kDa

Related Antibodies

View All Klrb1c Antibodies

Functions

  • Plays a stimulatory role on natural killer (NK) cells cytotoxicity. Activation by cross-linking of the receptor induces Ca(2+) mobilization and interferon-gamma production.

Key References

  • Kung SK, et al. 1999. J. Immunol. 162:5876. (Block)
  • Drobyski W, et al. 1996. Blood 87:5355. (Deplete)
  • Kanwar JR, et al. 2001. J. Natl. Cancer Inst. 93:1541. (IHC, IF)
  • Sentman CL, et al. 1989. Hybridoma 8:605. (IP)
  • Bankoti J, et al. 2010. Toxicol. Sci. 115:422. (FC)

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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