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Formalin-fixed, paraffin-embedded human skin stained with Nucleophosmin Mouse Monoclonal Antibody (NA24).
SDS-PAGE Analysis of Purified Nucleophosmin Mouse Monoclonal Antibody (NA24). Confirmation of Integrity and Purity of Antibody.
Immunofluorescence staining of HeLa cells. Nucleophosmin Mouse Monoclonal Antibody (NA24) followed by goat anti-mouse IgG-CF488 (green). Membrane stained with phalloidin (red).
Flow Cytometric Analysis of PFA-fixed HeLa cells. Nucleophosmin Mouse Monoclonal Antibody (NA24) followed by goat anti-mouse IgG-CF488 (blue); isotype control (red).
Recognizes a 33kDa glycoprotein, identified as Nucleophosmin (NPM). It is predominantly localized in the nucleus of cells in most tissues. NPM is involved in ribosomal assembly and rRNA transport. It is an abundant protein that is highly phosphorylated by Cdc2 kinase during mitosis. This phosphoprotein moves between the nucleus and the cytoplasm. It is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in exon 12 affecting the C-terminus of the protein are associated with an aberrant cytoplasmic location. Mutations in this gene are associated with acute myeloid leukemia.The antibody may be a useful aid for classification of acute myeloid leukemia.
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