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Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85伪 and p85尾), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110伪 and p110尾 interact with p85伪, and p110伪 has also been shown to interact with p85尾 in vitro. p110 �L expression is restricted to white blood cells. It has been shown to bind p85伪 and p85尾, but it apparently does not phosphorylate these subunits. p110 �L seems to have the capacity to autophosphorylate. p110纬 does not interact with the p85 subunits. It has been shown to be activated by 伪 and 尾纬 heterotrimeric G proteins.
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