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Plakophilin-1 (PKP1) Antibody [10B2]

In Stock
Catalog Number Formulation Size Price
5317-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
5317-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
5317-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
Western Blot of U87, HeLa and A431 cell lysates using Plakophilin-1 Mouse Monoclonal Antibody (10B2)

Western Blot of U87, HeLa and A431 cell lysates using Plakophilin-1 Mouse Monoclonal Antibody (10B2)

SDS-PAGE Analysis of Purified CD56 Monoclonal Antibody (NCAM1/784). Confirmation of Integrity and Purity of Antibody

SDS-PAGE Analysis of Purified CD56 Monoclonal Antibody (NCAM1/784). Confirmation of Integrity and Purity of Antibody

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Flow Cytometry Protocol
Immunofluorescence (IF)
1-3ug/ml
Western Blot (WB)
2-4ug/ml
Western Blot Protocol

Summary

Recognizes a protein of 75kDa, identified as Plakophilin-1. Its epitope maps between aa 1-27 human Plakophilin-1. Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Immunofluorescence, Western Blot
Species Reactivity
Human, Mouse
Research Areas
Apoptosis, Autophagy, Cardiovascular, Developmental Biology, Immunology, Nuclear Marker
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cell junction, Desmosome, Nucleus
Gene Name
PKP1
Positive Control
HeLa and A431 cells., U87
Immunogen
N-terminus of human Plakophilin-1 protein
Alternate Names
Plakophilin-1, Band 6 protein, B6P; Band 6 protein; PKP1; Plakophilin-1 (ectodermal dysplasia/skin fragility syndrome)

Database Links

Entrez Gene ID
5317
SwissProt
Q13835

Additional Information

Clone
10B2
Chromosome Location
1q32
Mol. Weight of Antigen
75kDa

Related Antibodies

View All PKP1 Antibodies

Functions

  • Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis.

Key References

  • Hadiji-Abbes, N. et al. 2014. Negative control glucose dependent mediated by the PreS2 region on the translation efficiency of the reporter Sh-bleomycin gene in Saccharomyces cerevisiae. FEMS Yeast Res. 14: 357-63.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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