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Flow Cytometric Analysis of PFA-fixed HeLa cells. PRMT6 Mouse Monoclonal Antibody (PCRP-PRMT6-2C9) followed by goat anti-mouse IgG-CF488 (blue); unstained cells (red).
SDS-PAGE Analysis. Purified PRMT6 Mouse Monoclonal Antibody (PCRP-PRMT6-2C9). Confirmation of Purity and Integrity of Antibody.
Immunofluorescence Analysis of PFA-fixed MCF7 cells stained using PRMT6 Mouse Monoclonal Antibody (PCRP-PRMT6-2C9) followed by goat anti-mouse IgG-CF488 (green). CF640R phalloidin (red).
SDS-PAGE Analysis. Purified PRMT6 Mouse Monoclonal Antibody (PCRP-PRMT6-2C9). Confirmation of Purity and Integrity of Antibody.
Analysis of Protein Array containing more than 19,000 full-length human proteins using PRMT6 Mouse Monoclonal Antibody (PCRP-PRMT6-2C9). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
A class of proteins termed type 1 protein arginine N-methyltransferase (PRMT) enzymes contribute to posttranslational modification of RNA-binding proteins, but differ in substrate specificities, oligomerization properties and subcellular localization. PRMTs contain an S-adenosylmethione motif which functions to add one or two methyl groups to guanidino nitrogens of arginine (R) side chains. PRMT6, also known as HRMT1L6, is a nuclear protein belonging to the PRMT family and is predominantly expressed in testis and kidney. It is known to methylate Histones H3, H4 and H2A. PRMT6 is the major dimethyltransferase for Histone H3 and specifically methylates Histone H3 at R2. Methylation at Histone H3 R2 acts to inhibit Histone H3 K4 trimethylation and ultimately leads to the transcriptional repression of genes that are activated by Histone H3 K4 trimethylation. In addition, PRMT6 methylates HIV TAT, possibly functioning as a form of cellular innate immunity to restrict levels of HIV replication.
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