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Recombinant Prolactin Receptor (hPRL Receptor) Antibody [PRLR/3785R]

In Stock
Catalog Number Formulation Size Price
5618-RBM6-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
5618-RBM6-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
5618-RBM6-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day
SDS-PAGE Analysis of Purified Prolactin Receptor Recombinant Rabbit Monoclonal (PRLR3785R). Confirmation of Integrity and Purity of Antibody.

SDS-PAGE Analysis of Purified Prolactin Receptor Recombinant Rabbit Monoclonal (PRLR3785R). Confirmation of Integrity and Purity of Antibody.

Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Prolactin Receptor Recombinant Rabbit Monoclonal (PRLR3785R).

Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Prolactin Receptor Recombinant Rabbit Monoclonal (PRLR3785R).

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

It recognizes a protein of 70kDa, identified as prolactin receptor. Prolactin is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. The initial step in its action is the binding to a specific membrane receptor (prolactin receptor), which belongs to the superfamily of class 1 cytokine receptors. The function of the prolactin receptor is mediated, at least in part, by two families of signaling molecules: Janus kinases and signal transducers and activators of transcription.

Product Properties & Targets

Antibody Type
Rabbit Monoclonals, Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Cardiovascular, Immunology, Cytokine Signaling
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Membrane, Secreted
Gene Name
PRLR
Positive Control
Testicular Carcinoma.
Immunogen
Recombinant full-length human PRLR protein
Alternate Names
Prolactin receptor, CPRLP, hPRL receptor, hPRLrI, Lactogen receptor, OPR, Pr-1, Pr-3, PRL-R, Prolactin receptor delta 7/11, RATPRLR, Secreted prolactin binding protein, Truncated testis-specific box 1-C prolactin receptor

Database Links

Entrez Gene ID
5618
SwissProt
P16471

Additional Information

Clone
PRLR/3785R
Chromosome Location
5p13.2
Mol. Weight of Antigen
70kDa

Related Antibodies

View All PRLR Antibodies

Functions

  • This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.

Key References

  • Breast Cancer Res. 2008;10(4):R68.
  • Histopathology. 2008;53(1):56-61

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody is stable for 24 months. ,Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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