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Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with TFF1/pS2 Mouse Monoclonal Antibody (TFF1/2133).
SDS-PAGE Analysis Purified TFF1/ps2 Mouse Monoclonal Antibody (TFF1/2133). Confirmation of Purity and Integrity of Antibody.
Flow Cytometric Analysis of PFA-fixed MCF-7 cells using TFF1/pS2 Mouse Monoclonal Antibody (TFF1/2133) followed by goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red).
Immunofluorescence staining of paraformaldehyde-fixed MCF-7 cells with TFF1/pS2 Mouse Monoclonal Antibody (TFF1/2133) followed by goat anti-Mouse IgG-CF488 (Green). Membrane are labeled with phalloidin (Red).
Immunofluorescence staining of paraformaldehyde-fixed MCF-7 cells with TFF1/pS2 Mouse Monoclonal Antibody (TFF1/2133) followed by goat anti-Mouse IgG-CF488 (Green). Nucleus is labeled with Reddot(Red).
Analysis of Protein Array containing more than 19,000 full-length human proteins using TFF1/pS2 Mouse Monoclonal Antibody (TFF1/2133). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SDÂ’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SDÂ’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
It recognizes a polypeptide of 6.5kDa, identified as pS2 estrogen-regulated protein. Its epitope is located in the c-terminus of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.
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