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Formalin-fixed, paraffin-embedded human tonsil stained with CD19 Recombinant Rabbit Monoclonal Antibody (CD19/4260R). Inset: PBS instead of primary antibody; secondary only negative control.
Western Blot Analysis of Raji cell lysate using CD19 Recombinant Rabbit Monoclonal Antibody (CD19/4260R7).
Analysis of Protein Array containing more than 19,000 full-length human proteins using CD19 Recombinant Rabbit Monoclonal Antibody (CD19/4260R). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
SDS-PAGE Analysis of Purified CD19 Recombinant Rabbit Monoclonal Antibody (CD19/4260R). Confirmation of Purity and Integrity of Antibody.
Western blot analysis of Human Tonsil tissue lysates using CD19 Recombinant Rabbit Monoclonal Antibody (CD19/4260R).
CD19 is a transmembrane glycoprotein that contains two extracellular immunoglobulin-like domains. CD19 is present in both benign and malignant B-cells and is considered to be the most reliable surface marker of this lineage over a wide range of maturational stages. In normal lymphoid tissue, CD19 is observed in germinal centers, in mantle zone cells, and in scattered cells of the inter-follicular areas. Anti-CD19 exhibits an overall immunoreactivity pattern similar to those of the antibodies against CD20 and CD22. However, in contrast to CD20, expression of CD19 is continuous throughout B-cell development and through terminal differentiation of B-cells into plasma cells. Anti-CD19 positivity is seen in the vast majority of B-cell neoplasms commonly at a lower intensity than normal B-cell counterparts. Plasma cell neoplasms are nearly always negative, as are T-cell neoplasms.
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