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Recombinant MYH7 Antibody [MYH7/13050R]

In Stock
Catalog Number Formulation Size Price
4625-RBM7-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
4625-RBM7-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
4625-RBM7-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
MYH7 Antibody in SDS-PAGE

MYH7 Antibody in SDS-PAGE

SDS-PAGE Analysis Purified MYH7 Recombinant Rabbit Monoclonal Antibody (MYH7/13050R). Confirmation of Purity and Integrity of Antibody.

MYH7 Antibody in Immunohistochemistry (IHC (P))

MYH7 Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human skeletal muscle stained with Myosin Heavy Chain 7 Recombinant Rabbit Monoclonal Antibody (MYH7/13050R). Inset: PBS instead of primary antibody; secondary only negative control.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Myosin heavy chains are ubiquitous Actin-based motor proteins that convert the chemical energy derived from ATP hydrolysis into the mechanical energy that drives diverse motile processes in eukaryotic cells, including cytokinesis, vesicular transport and cellular locomotion. Muscle myosin is a heterohexamer consisting of two myosin heavy chains and two associated nonidentical pairs of myosin light chains. The seven myosin heavy chain isoforms that predominate in mammalian skeletal muscles include two developmental isoforms, MHC-embryonic (MYH3) and MHC-perinatal (MYH8); three adult skeletal muscle isoforms, MHC IIa (MYH2), MHC IIb (MYH4) and MHC IIx/d (MYH1); and MHC-β/slow (MYH7 or MHC-β), which is also expressed in cardiac muscle. Research indicates that mutations of the MYH7 gene causes hypertrophic cardiomyopathy.

Product Properties & Targets

Antibody Type
Rabbit Monoclonals, Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Cardiovascular
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Cytoplasm, Myofibril, Cytoplasm > myofibril. Thick filaments of the myofibrils.
Gene Name
MYH7
Positive Control
Skeletal muscle.
Immunogen
Recombinant fragment (around aa1150-1350) of human MYH7 protein (exact sequence is proprietary)
Alternate Names
Myosin-7, Myosin heavy chain 7, Myosin heavy chain slow isoform, Myosin heavy chain, cardiac muscle beta isoform, Beta myosin heavy chain; cardiac muscle beta isoform; CMD1S; CMH1; MPD1; MyHC-beta; MyHC-slow; MYHCB; Myopathy, distal 1; Myosin heavy chain (AA 1-96); Myosin heavy chain slow isoform; Myosin heavy chain, cardiac muscle beta isoform; Myosin, heavy chain 7, cardiac muscle, beta; Myosin, heavy polypeptide 7, cardiac muscle, beta; Myosin-7; Rhabdomyosarcoma antigen MU RMS 40.7A; SPMD; SPMM

Database Links

Entrez Gene ID
4625
SwissProt
P12883

Additional Information

Clone
MYH7/13050R
Chromosome Location
14q11.2
Mol. Weight of Antigen
223kDa

Related Antibodies

View All MYH7 Antibodies

Functions

  • Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle.

Key References

  • Bian, Z.Y., et al. 2012. Disruption of mindin exacerbates cardiac hypertrophy and fibrosis. J. Mol. Med. 90: 895-910.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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