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S100P / MIG9 Antibody [S100P/7375]

In Stock
Catalog Number Formulation Size Price
6286-MSM5-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
6286-MSM5-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
6286-MSM5-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
Formalin-fixed, paraffin-embedded human placenta stained with S100P Recombinant Mouse Monoclonal Antibody (S100P/7375). Inset: PBS instead of primary antibody; secondary only negative control.

Formalin-fixed, paraffin-embedded human placenta stained with S100P Recombinant Mouse Monoclonal Antibody (S100P/7375). Inset: PBS instead of primary antibody; secondary only negative control.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

S100P is a 95-amino-acid protein and a member of the S100 family. S100P has been shown to mediate tumor growth, metastasis and invasion through the binding of Ca2+ ions, receptor for advanced glycation end products, cytoskeletal protein ezrin, calcyclin-binding protein/Siah-1-interacting protein and cathepsin D.S100P highly expressed in human placenta, gastrointestinal tract, and esophageal mucosa, but always negative in pancreas and liver. Overexpression of S100P has been detected in several cancers such as breast, colon, prostate, pancreatic and lung carcinomas, and the protein has been functionally implicated in carcinogenic processes. S100P could potentially serve as diagnostic marker, prognostic/predictive indicator and therapy target for different carcinomas.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Immunology, Nuclear Marker
Isotype / Light Chain
IgG2a / Kappa
Cellular Localization
Nucleus. Cytoplasm. Colocalizes with S100PBP in the nucleus.
Gene Name
S100P
Positive Control
Human pancreatic adenocarcinoma|placenta or spleen tissue.
Immunogen
Recombinant fragment (around aa1-95) of human MIG9 protein (exact sequence is proprietary)
Alternate Names
Protein S100-P, Migration-inducing gene 9 protein, Protein S100-E, S100 calcium-binding protein P, Migration inducing gene 9 (MIG9); S100E; S100 calcium binding protein P

Database Links

Entrez Gene ID
6286
SwissProt
P25815

Additional Information

Clone
S100P/7375
Chromosome Location
4p16.1
Mol. Weight of Antigen
10kDa

Related Antibodies

View All S100P Antibodies

Functions

  • May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE).

Key References

  • Jiang H et.al. J Cancer Res Clin Oncol. 2012 Jan;138(1):1-9

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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