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Serum Amyloid P / APCS Antibody [APCS/3240]

In Stock
Catalog Number Formulation Size Price
325-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
325-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
325-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Serum amyloid P (SAP) is a glycoprotein belonging to the pentraxin family of proteins, which has a characteristic pentameric organization and calciumdependent ligand binding. Secreted by liver epithelial cells, SAP is found in serum and urine. Although the function of SAP has not been clearly established, it has been shown to interact with DNA and histones and is thought to play a role in scavenging nuclear material released from damaged circulating cells. Also designated PTX2, SAP is a precursor of the protein amyloid P component (AP), which is universally associated with the amyloid deposits in all forms of amyloidoses, including Alzheimer s disease. SAP is a decamer of ten identical, noncovalently linked subunits, each of which may be post-translationally modified by glycosylation.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG2b / Kappa
Cellular Localization
Secreted
Gene Name
Positive Control
Human endometrial carcinoma tissue (IHC).
Immunogen
Recombinant fragment of human APCS protein (around aa 143-223) (exact sequence is proprietary)
Alternate Names
Serum amyloid P-component, 9.5S alpha-1-glycoprotein, 9.5S alpha 1 glycoprotein; Amyloid P component serum (APCS); Pentaxin related; Pentraxin 2 (PTX2); Serum Amyloid P (SAP); Serum amyloid P component

Database Links

Entrez Gene ID
325
SwissProt

Additional Information

Clone
APCS/3240
Chromosome Location
1q23.2
Mol. Weight of Antigen
200kDa (oligomeric); 26kDa (non-covalently bound subunit); 30kDa (glycosylated SAP subunit)

Functions

  • Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.

Key References

  • Castano AP et al. Serum amyloid P inhibits fibrosis through Fc gamma R-dependent monocyte-macrophage regulation in vivo. Sci Transl Med 1:5ra13 (2009).

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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