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SDS-PAGE Analysis Purified SSTR2 Mouse Monoclonal Antibody (SSTR2/7532). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human pancreas stained with Somatostatin Receptor 2 Mouse Monoclonal Antibody (SSTR2/7532). Inset: PBS instead of primary antibody; secondary only negative control.
Formalin-fixed, paraffin-embedded human heart stained with Somatostatin Receptor 2 Mouse Monoclonal Antibody (SSTR2/7532). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.
SSTRs (for somatostatin receptors) represent a family of G protein-coupled receptors which mediate the diverse biological actions of somatostatin (SST). There are five distinct subtypes of SSTRs that bind two natural ligands, SST-14 and SST-28. SSTR2 gives rise to spliced variants, SSTR2A and 2B. SSTRs share common signaling pathways such as the ability to inhibit adenylyl cyclase via GTP binding proteins. Some of the subtypes are also coupled to tyrosine phosphatase (SSTR1,2), Ca2+ channels (SSTR2), Na+/H+ exchanger (SSTR1), PLA-2 (SSTR4), and MAP kinase (SSTR4). Individual target cells typically express more than one SSTR subtype and often all five isoforms. Subtypes of SSTR can form functional homo- and heterodimers.
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