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TNFS15 / VEGI (Vascular Endothelial Growth Inhibitor) Antibody [VEGI/13117]

In Stock
Catalog Number Formulation Size Price
9966-MSM7-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
9966-MSM7-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
9966-MSM7-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
VEGI Antibody in Immunohistochemistry (IHC (P))

VEGI Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human testis stained with VEGI Mouse Monoclonal Antibody (VEGI/13117). Inset: PBS instead of primary antibody; secondary only negative control.

VEGI Antibody in Immunohistochemistry (IHC (P))

VEGI Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human placenta stained with VEGI Mouse Monoclonal Antibody (VEGI/13117). Inset: PBS instead of primary antibody; secondary only negative control.

VEGI Antibody in SDS-PAGE

VEGI Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified VEGI Mouse Monoclonal Antibody (VEGI/13117). Confirmation of Purity and Integrity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

VEGI is an anti-angiogenic cytokine that belongs to tumor necrosis factor superfamily, member 15 (TNFSF15). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of VEGI has been reported as a marker of poor prognosis in breast cancer.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Immuno Oncology, Immunology, Cytokine Signaling
Isotype / Light Chain
IgG2b / Kappa
Cellular Localization
Membrane, Secreted
Gene Name
TNFSF15
Positive Control
Endothelial cells. Monocytes. Human placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen or prostate.
Immunogen
Recombinant fragment (around aa100-251) of human VEGI protein (exact sequence is proprietary)
Alternate Names
Tumor necrosis factor ligand superfamily member 15, TNF ligand-related molecule 1, Vascular endothelial cell growth inhibitor, TNF ligand-related molecule 1 (TL1A); Tumor necrosis factor (ligand) superfamily member 15 (TNFSF15); Vascular endothelial growth inhibitor 192a; Vascular endothelial growth inhibitor (VEGI); VEGI192A

Database Links

Entrez Gene ID
9966
SwissProt
O95150

Additional Information

Clone
VEGI/13117
Chromosome Location
9q32
Mol. Weight of Antigen
22kDa

Related Antibodies

View All TNFSF15 Antibodies

Functions

  • Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.

Key References

  • Zhai, Y., et al. 1999. Inhibition of angiogenesis and breast cancer xenograft tumor growth by VEGI, a novel cytokine of the TNF superfamily. Int. J. Cancer 82: 131-136. 5.
  • Parr C, Gan CH, Watkins G, Jiang WG. Reduced vascular endothelial growth inhibitor (VEGI) expression is associated with poor prognosis in breast cancer patients. Angiogenesis. 2006;9(2):73-81.
  • Zhai, Y., et al. 1999. VEGI, a novel cytokine of the tumor necrosis factor family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo. FASEB J. 13: 181-189.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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