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It recognizes a 170kDa protein, which is identified as topoisomerase II伪. It shows no cross-reaction with Topoisomerase II 尾 or I. Topo II 伪 plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells. Topo II 伪 is also implicated in drug resistance of tumor cells and has been shown to be over-expressed in many human cancers. Decreased expression of Topo IIa is the predominant mechanism of resistance to several chemotherapeutic agents.
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