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TOX3 / TNRC9 Antibody [TOX3/1124]

In Stock
Catalog Number Formulation Size Price
27324-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
27324-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
27324-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
TOX3 / TNRC9 Antibody

Western Blot Analysis (A) Recombinant protein (B) A549 (C) A431 TOX3 Mouse Monoclonal Antibody (TOX3/1124).

TOX3 / TNRC9 Antibody - Image 2

SDS-PAGE Analysis of Purified TOX3 Mouse Monoclonal Antibody (TOX3/1124).

Applications & Dilutions

Applications Tested Dillution Protocol Note
Western Blot (WB)
2-4ug/ml
Western Blot Protocol

Summary

It recognizes a 63kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
ELISA, Western Blot
Species Reactivity
Human
Research Areas
Nuclear Marker
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Nucleus
Gene Name
TOX3
Positive Control
MDA-MB-435 cells. Brain or breast or gastric Carcinoma., SH-SY5Y
Immunogen
Recombinant fragment of human TOX3 protein (around aa 251-389) (Exact sequence is proprietary)
Alternate Names
TOX high mobility group box family member 3, CAG trinucleotide repeat-containing gene F9 protein, Trinucleotide repeat-containing gene 9 protein, TOX3; CAG trinucleotide repeat-containing gene F9 protein; CAGF9; TOX high mobility group box family member 3; Trinucleotide repeat containing 9 (TNRC9)

Database Links

Entrez Gene ID
27324
SwissProt
O15405

Additional Information

Clone
TOX3/1124
Chromosome Location
16q12.1
Mol. Weight of Antigen
63kDa

Related Antibodies

View All TOX3 Antibodies

Functions

  • Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region.

Key References

  • O'Flaherty, E., et al. 2003. TOX defines a conserved subfamily of HMG-box proteins. BMC Genomics 4: 13.
  • Smid, M., et al. 2006. Genes associated with breast cancer metastatic to bone. J. Clin. Oncol. 24: 2261-2267.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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