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TSH-Receptor, B-Chain (Thyroid Marker) Antibody [TSHRB/1405]

In Stock
Catalog Number Formulation Size Price
7253-MSM5-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
7253-MSM5-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
7253-MSM5-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day
SDS-PAGE Analysis of Purified TSHRB Monoclonal Antibody (TSHRB/1405). Confirmation of Purity and Integrity of Antibody.

SDS-PAGE Analysis of Purified TSHRB Monoclonal Antibody (TSHRB/1405). Confirmation of Purity and Integrity of Antibody.

Formalin-fixed, paraffin-embedded human Thyroid Carcinoma stained with TSHRB Monoclonal Antibody (TSHRB/1405).

Formalin-fixed, paraffin-embedded human Thyroid Carcinoma stained with TSHRB Monoclonal Antibody (TSHRB/1405).

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Grave's disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Cancer, Signal Transduction
Isotype / Light Chain
IgG2a / Kappa
Cellular Localization
Basolateral cell membrane, Cell membrane
Gene Name
TSHR
Positive Control
293T cells. Thyroid gland.
Immunogen
Recombinant human TSHR, B-Chain protein
Alternate Names
Thyrotropin receptor, Thyroid-stimulating hormone receptor, CHNG1; hTSHRI; LGR3; Thyroid-stimulating hormone receptor; Thyrotropin receptor; Thyrotropin receptor I; TSHR

Database Links

Entrez Gene ID
7253
SwissProt
P16473

Additional Information

Clone
TSHRB/1405
Chromosome Location
14q31
Mol. Weight of Antigen
42kDa

Related Antibodies

View All TSHR Antibodies

Functions

  • Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:11847099, PubMed:12045258). Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099). Plays a central role in controlling thyroid cell metabolism (By similarity).

Key References

  • Tanaka, K., et al. 1999. Subunit structure of thyrotrophin receptors expressed on the cell surface. J. Biol. Chem. 274: 33979-33984.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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