![Formalin-fixed, paraffin-embedded human melanoma stained with Tyrosinase Mouse Monoclonal Antibody (T311) [10X].](https://www.neobiotechnologies.com/wp-content/uploads/2022/03/img-7299-MSM1-P0-1-300x300.jpg "Formalin-fixed, paraffin-embedded human melanoma stained with Tyrosinase Mouse Monoclonal Antibody (T311) [10X].")
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Formalin-fixed, paraffin-embedded Melanoma stained with Tyrosinase Rabbit Recombinant Monoclonal Antibody (TYR/2024R).
SDS-PAGE Analysis of Purified Tyrosinase Rabbit Recombinant Monoclonal Antibody (TYR/2024R).
Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.
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