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Formalin-fixed, paraffin-embedded human pancreas stained with vWF Mouse Monoclonal Antibody (3E2D10).
Formalin-fixed, paraffin-embedded human tonsil stained with vWF Mouse Monoclonal Antibody (3E2D10).
SDS-PAGE Analysis of Purified vWF Mouse Monoclonal Antibody (3E2D10). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human brain stained using Von Willebrand Factor Mouse Monoclonal Antibody (3E2D10) followed by goat anti-mouse IgG-CF488 (green). DAPI used to label nuclei.
von Willebrand Factor (vWF) is a multimeric glycoprotein that is found in endothelial cells, plasma and platelets. It acts as a carrier protein for Factor VIII and promotes platelet adhesion and aggregation. vWF undergoes a variety of posttranslational modifications that influence the affinity and availability for Factor VIII, including cleavage of the propeptide and formation of N-terminal disulfide bonds. This antibody helps to establish the endothelial nature of some lesions of disputed histogenesis, e.g. Kaposi s sarcoma and cardiac myxoma. It is widely used for differentiating vascular lesions from those of other tissue differentiation within a panel of other vascular markers although not all tumors of endothelial differentiation contain this antigen.
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