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ZHX3 (Transcriptional Repressor) Antibody [PCRP-ZHX3-1D11]

In Stock
Catalog Number Formulation Size Price
23051-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
23051-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
23051-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Flow Cytometry (Flow)
1-2ug/million cells
Western Blot (WB)
2-4ug/ml

Summary

Zinc-fingers and homeobox (ZHX) proteins are transcription factors that interact with the activation domain of the A subunit of nuclear factor-Y (NF-YA). ZHX1-3 are ubiquitously expressed proteins expressed in various tissues. They act as transcriptional repressors and localize to the nucleus. The ZHX proteins contain two Cys2-His2-type zinc-finger motifs and five homeodomains (HDs). These domains allow the ZHX proteins to form homodimers, but they can also form heterodimers with each other. However, this dimerization is not required for repressor activity. Hypermethylation-mediated silencing of ZHX2 is an epigenetic event involved in hepatocellular carcinoma (HCC).

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG2b /
Cellular Localization
Nucleus
Gene Name
Positive Control
brain or thyroid., Human kidney
Immunogen
Recombinant full-length human ZHX3 protein
Alternate Names
Zinc fingers and homeoboxes protein 3, Triple homeobox protein 1, Zinc finger and homeodomain protein 3, KIAA0395; TIX1; Triple homeobox protein 1; ZHX 3; Zhx3; Zinc finger and homeodomain protein 3; Zinc fingers and homeoboxes protein 3

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
PCRP-ZHX3-1D11
Chromosome Location
20q12
Mol. Weight of Antigen
105kDa

Functions

  • Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA.

Key References

  • ZHX3 promotes the progression of urothelial carcinoma of the bladder via repressing of RGS2 and is a novel substrate of TRIM21. Deng M, et al. Cancer Sci, 2021 May. PMID 33440047

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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