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Flow Cytometric Analysis of PFA-fixed Raji cells. ZMYM3 Mouse Monoclonal Antibody (PCRP-ZMYM3-2F10) followed by goat anti-mouse IgG-CF488 (blue); unstained cells (red).
Immunofluorescence Analysis of PFA-fixed HeLa cells using ZMYM3 Mouse Monoclonal Antibody (PCRP-ZMYM3-2F10) followed by goat anti-mouse IgG-CF488 (green). CF640A phalloidin (red).
Flow Cytometric Analysis of PFA-fixed HeLa cells. ZMYM3 Mouse Monoclonal Antibody (PCRP-ZMYM3-2F10) followed by goat anti-mouse IgG-CF488 (blue); unstained cells (red).
Formalin-fixed, paraffin-embedded human breast carcinoma stained with ZMYM3 Mouse Monoclonal Antibody (PCRP-ZMYM3-2F10).
Analysis of Protein Array containing more than 19,000 full-length human proteins using ZMYM3 Mouse Monoclonal Antibody (PCRP-ZMYM3-2F10). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZMYM3 (zinc finger MYM-type protein 3), also known as ZNF261 (zinc finger protein 261), XFIM, DXS6673E or MYM, is a 1,370 amino acid nuclear protein that contains nine MYM-type zinc fingers. Expressed in a variety of tissues, including heart, muscle and brain, ZMYM3 is thought to function as part of a histone deacetylase-containing complex that contains other proteins, such as HDAC1 and HDAC2, and may play a role in gene silencing through the modification of chromatin structure. Defects in the gene encoding ZMYM3 that lead to chromosomal translocations may be a cause of X-linked mental retardation. Two isoforms of ZMYM3 exist due to alternative splicing events.
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