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ZNF622 / ZPR9 (Transcription Factor) Antibody [PCRP-ZNF622-1C11]

In Stock
Catalog Number Formulation Size Price
90441-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
90441-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
90441-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-3ug/ml

Summary

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF622 (zinc-finger protein 622), also known as ZPR9 (zinc-fingerlike protein 9), is a 477 amino acid protein that localizes to both the nucleus and the cytoplasm. Expressed in liver, spleen, lung, kidney and brain, ZNF622 is thought to activate the bound transcription factor B-Myb and, through this activation, may play a role in embryonic development. ZNF622 contains two U1-type zinc fingers and exists as either a homodimer or a heterodimer that can be phosphorylated by MELK (maternal embryonic leucine zipper kinase). Overexpression of ZNF266 may be associated with liver metastases, carcinomatoses and colorectal carcinomas.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG2a /
Cellular Localization
Cytoplasm, Nucleus
Gene Name
Positive Control
HeLa or Raji cells. Ubiquitious nuclear expression.
Immunogen
Recombinant full-length human ZNF622 protein
Alternate Names
Zinc finger protein 622, Zinc finger-like protein 9, MGC108936; Zinc finger protein 622; Zinc finger-like protein 9; ZNF622; ZPR9

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
PCRP-ZNF622-1C11
Chromosome Location
5p15.1
Mol. Weight of Antigen
52kDa

Functions

  • May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development.

Key References

  • Thiesen, H.J. 1990. Multiple genes encoding zinc-finger domains are expressed in human T cells. New Biol. 2: 363-374.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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