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SDS-PAGE Analysis Purified ZNF704 Mouse Monoclonal Antibody (PCRP-ZNF704-3C10). Confirmation of Integrity and Purity of Antibody.
Flow cytometric analysis of PFA-fixed HeLa cells. ZNF704 Mouse Monoclonal Antibody (PCRP-ZNF704-3C10) followed by goat anti-mouse IgG-CF488 (blue); isotype control (red).
Immunofluorescence Analysis of PFA-fixed HeLa cells stained using ZNF704 Mouse Monoclonal Antibody (PCRP-ZNF704-3C10) followed by goat anti-mouse IgG-CF488 (green). CF640 phalloidin (red).
Formalin-fixed, paraffin-embedded human prostate carcinoma stained with ZNF704 Mouse Monoclonal Antibody (PCRP-ZNF704-3C10). HIER: Tris/EDTA, pH9.0, 45min. 2 °: HRP-polymer, 30min. DAB, 5min.
Analysis of Protein Array containing more than 19,000 full-length human proteins using ZNF704-Monospecific Mouse Monoclonal Antibody (PCRP-ZNF704-3C10). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Kr ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. As a member of the Kr ppel C2H2-type zinc-finger protein family, ZNF704 (zinc finger protein 704) is a 412 amino acid nuclear protein that contains one C2H2-type zinc finger. The gene encoding ZNF704 maps to human chromosome 8, which is made up of nearly 146 million bases and encodes about 800 genes. Chromosome 8 is also associated with Pfeiffer syndrome, congenital hypothyroidism and Waardenburg syndrome.
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