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26 December, 2023 by Anshul (neobio)
Are you unsure about the key player in your body’s defense machinery? Let’s talk about dendritic cells. These unsung heroes form the backbone of our immune system. But how do we identify them amidst the sea of other cell types in our body? The answer lies in cell markers, the molecular flags that cells carry, allowing us to identify distinct cell types and study their specialised roles. The CD11c dendritic cell marker is one such identifier, a beacon that highlights a critical cell group involved in our fight against diseases.
CD11c, a subtype of the integrin alpha X protein, is a widely recognized dendritic cell marker. While it’s not exclusively present on these cells, its relative abundance on them allows researchers to isolate and study these immune powerhouses more efficiently. CD11c helps us zero in on a subset of dendritic cells, which play a critical role as our body’s key defenders against various pathological conditions. This marker is a kind of molecular name tag that enables us to point out the cells that connect the innate and adaptive branches of our immune system.
Importantly, understanding CD11c is also essential for scientific research. With the acclaimed biotech firm, NeoBiotechnologies, offering highly validated monoclonal antibodies, studying the function and expression of CD11c has become streamlined and accessible.
This cheat sheet aims to demystify the CD11c marker for you, providing you with a straightforward guide that takes you through its function and importance in the immune system.
Key takeaways about CD11c dendritic cell marker:
– CD11c is a well-known marker for dendritic cells (though not exclusively present on them).
– It’s critical for identifying and studying the subset of dendritic cells in the immune system.
– Dendritic cells, highlighted by CD11c, play a key role in the immune response against various pathological conditions.
– Understanding CD11c aids in specialized research and has been made accessible through companies like NeoBiotechnologies providing validated monoclonal antibodies.
As we delve deeper into the role of the CD11c marker, it’s crucial to understand the pivotal part it plays in immune responses and cell identification. This marker, used widely in scientific research, is an integral part of the tools offered by NeoBiotechnologies.
Dendritic cells, often identified by the presence of the CD11c marker, serve as the conductors of the immune symphony. These cells orchestrate systemic and tissue immune responses under various pathological conditions. They are the main antigen-presenting cells, tasked with processing antigen material and presenting it on the cell surface to the T cells of the immune system. This function is fundamental to the immune system’s ability to fight off infections and diseases.
Our expert, Dr. Atul K. Tandon, Founder and CEO at NeoBiotechnologies, emphasizes, “CD11c+ dendritic cells play a critical role in shaping the adaptive immune response. Their ability to present antigens makes them pivotal in the fight against infections.”
Although CD11c is most abundant on dendritic cells, it is not exclusive to them. It is also expressed on various immune cells, including a subset of T and B cells, natural killer (NK) cells, and mast cells. The expression of CD11c in these cells is closely related to their functionality, particularly in the context of viral clearance and tumor regression.
Dr. Tandon explains, “CD11c expression on different immune cells can provide valuable insights into the status of the immune response – whether the body is fighting an infection or reacting to a tumor.”
CD11b and CD11c, both part of the integrin family, are closely related and recognize overlapping ligands, including iC3b, denatured proteins, fibrinogen, and intercellular adhesion molecule-1 (ICAM-1). However, there are key differences in their expression profiles. CD11b is predominantly expressed on myeloid cells, and also on NK cells, mast cells, and a subset of T and B cells. CD11c, on the other hand, is most abundant on dendritic cells.
Dr. Tandon adds, “The distinction between CD11b and CD11c is crucial for researchers, as it can provide nuanced insights into cellular behavior and immune responses. At NeoBiotechnologies, we provide CD11c dendritic cell marker and CD11b monoclonal antibodies, aiding researchers in their quest to understand and combat diseases.”
In conclusion, CD11c is more than just a marker – it is an integral part of the immune system’s orchestra, playing a key role in immune responses, and serving as a critical tool in scientific research.
CD11c is not limited to dendritic cells; its expression extends to other immune cells, contributing to various physiological and pathological conditions. In the brain, activated microglia, the primary immune cells, exhibit CD11c expression when the organ is diseased (Benmamar-Badel et al., 2020). This discovery adds to the growing body of research highlighting the role of CD11c in neuroinflammation and related disorders.
Moreover, CD11c expression has also been detected in hematopoietic stem and progenitor cells (HSPCs), especially under stress conditions (Hou et al., 2020). This finding suggests a critical role of CD11c in regulating the body’s response to stress at the cellular level.
In the field of oncology, the CD11c dendritic cell marker has proven to be invaluable. It is a critical diagnostic tool for identifying hairy cell leukemia, acute myeloid leukemia, and some chronic lymphocytic leukemias (Maitre et al., 2019; Master et al., 1989; Umit et al., 2017). This marker’s utility extends beyond research purposes; it offers clinicians a practical tool for diagnosing and monitoring treatment response in these malignancies.
Beyond its diagnostic role, CD11c expression can also help predict survival rates in cancer patients. For instance, the level of CD11c expression in tumors can serve as a prognostic marker, helping doctors make more informed decisions about treatment plans and patient care.
The CD11c marker is not just useful for disease diagnosis and prognosis; it also plays a critical role in developing treatments. For example, CD11c+ dendritic cells have been used in antibody therapies in mouse models. These cells can be targeted specifically using CD11c monoclonal antibodies from NeoBiotechnologies, offering a promising approach for treating various diseases.
In summary, the CD11c dendritic cell marker plays a crucial role in disease diagnosis, prognosis, and treatment. Whether it’s identifying disease, predicting patient outcomes, or developing new therapeutic strategies, CD11c continues to prove its importance in medical research and practice. As such, reliable and specific CD11c monoclonal antibodies, such as those provided by NeoBiotechnologies, are essential tools for research scientists.
Understanding the role of CD11c, a widely established dendritic cell marker, extends beyond identifying dendritic cell subsets in the immune system. It has been found to be present in other immune cells, including macrophages, monocytes, neutrophils, and certain T and NK cells. CD11c plays a crucial role in cellular adherence, migration, and phagocytosis. Furthermore, it has been linked to inflammation and immune responses in autoimmune diseases such as rheumatoid arthritis or multiple sclerosis.
Recent studies have also highlighted the significance of CD11c in disease diagnosis and treatment. CD11c expression has been detected in diseased brain activated microglia and on short-term hematopoietic stem and progenitor cells. Moreover, in the field of oncology, CD11c serves as an important marker for the diagnosis of certain forms of leukemia, including hairy cell leukemia and acute myeloid leukemia.
NeoBiotechnologies, a leader in the production of highly validated and specific monoclonal antibodies, recognizes the importance of CD11c in advancing our understanding of the immune system and its role in disease. The company offers a range of CD11c antibodies, including mouse-specific ones, which are particularly suited for distinguishing murine from human cells in humanized mouse models. These antibodies have been meticulously tested and validated, ensuring that they are reliable and suitable for a variety of applications including Immunohistochemistry, Flow Cytometry, Western Blotting, or Immunofluorescence.
In conclusion, CD11c is more than just a dendritic cell marker. Its role in immune responses and disease processes makes it a valuable tool in both research and clinical settings. NeoBiotechnologies continues to invest in the development and production of high-quality CD11c antibodies, contributing to the advancement of scientific understanding and the development of new therapeutic strategies. For further reading and product information, visit our CD11c dendritic cell marker and dendritic cell markers pages.
